1. Epidermodysplasia Verruciformis
Epidermodysplasia verruciformis (also called Lewandowsky-Lutz dysplasia or Lutz-Lewandowsky epidermodysplasia verruciformis) is an extremely rare autosomal recessive genetic hereditary skin disorder associated with a high risk of carcinoma of the skin. It is characterized by abnormal susceptibility to human papillomaviruses (HPVs) of the skin. The people resemble bark of trees .
Progeria (also known as “Hutchinson–Gilford progeria syndrome” and “Hutchinson–Gilford syndrome”) is an extremely rare, severe, genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. The disorder has a very low incidence and occurs in one per eight million live births. Those born with progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties. It is a genetic condition that occurs as a new mutation and is not usually inherited, although there is a uniquely inheritable form. This is in contrast to another rare but similar premature aging syndrome, dyskeratosis congenita (DKC), which is inheritable and will often be expressed multiple times in a family line.
It caused by a single gene affect in child’s genetic code resulting in hastening of normal aging process thus causing premature aging.
3. Aquagenic Urticaria
Aquagenic urticaria, also known as water allergy, the sufferer can’t go from a nice hot water bath or a shower or enjoy swimming, even sweating after a tiresome work brings a painful rash, it is an extremely rare form of physical urticaria. It is sometimes described as an allergy, although it is not a histamine releasing allergic reaction like other forms of urticaria; it is more a hypersensitivity to the ions found in non-distilled water. In affected persons, water on the skin causes hives to appear within 15 minutes and last for up to two hours. It is very unusual.
4. Alice in The Wonderland Syndrome (AIWS) Or Todd’s Syndrome:
Alice in Wonderland syndrome, also known as Todd’s syndrome, is a disorienting neurological condition which affects human perception. Sufferers may experience micropsia, macropsia, and/or size distortion of other sensory modalities. A temporary condition, it is often associated with migraines, brain tumors, and the use of psychoactive drugs
Micropsia is a neurological condition affecting human visual perception in which humans, inanimate and animate objects are perceived to be substantially smaller than they actually are. Micropsia can be caused by either optical distortion of images in the eye (as by glasses or certain ocular conditions) or by a neurological dysfunction. Similarly macropsia is the reverse condition characterized by objects appearing substantially larger than they actually are e.g a car may seem as big as a mountain.
5. Arnold Chiari Malformation
Arnold-Chiari malformation is a malformation of the brain. It consists of a downward displacement of the brain into the spinal cord. This boy Rhett Lamb is not oridinary in the fact he can’t sleep a wink. He has been awake for 4 years 24 hours a day. His condition has baffled the parents and the doctors who have finally came after a complicated discussion to the diagnosis of this young boy as Chiari Syndrome.
When it happens it can cause headaches,vomiting, muscle weakness in the head and face, difficulty swallowing,mental impairment,paralysis of arms, paralysis of legs, progressive brain impairment, involuntary eye movements – usually rapid and downward, dizziness, double vision, deafness, impaired coordination, and in some cases death.